Anti-CUX1 antibody produced in mouse
SIGMA/SAB1405681 - purified immunoglobulin, buffered aqueous solution
Synonym: CASP; CDP; CDP/Cut; CDP1; COY1; CUTL1; CUX; Clox; Cux/CDP
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to CUTL1 on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting Western Blot analysis of CUX1 expression in transfected 293T cell line by CUX1 polyclonal antibody. Lanes Lane 1: CUTL1 transfected lysate (74.36 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~77.2 kDa |
| NCBI accession no. | BC025422.2   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | P39880 |
| Biochem/physiol Actions: | Cut homeobox 1 (CUX1) binds to DNA and is involved in DNA repair. It stimulates the 8-oxoguanine-DNA glycosylase 1 (OGG1), a prime enzyme that acts on oxidative purine lesions and may have an indirect influence on radioresistance. Haploinsufficiency of CUX1 may have an impact on developmental delay (DD) and mild intellectual disability(ID). The multiple isoforms of CUX1 may have implications on various physiological pathologies like polycystic kidney disease and tumor development. In cortical neurons, CUX1 may play a key role in regulating spine development, dendritic branching, and synapse formation. CUX1 is a tumor suppressor gene and its deletion is implicated in high-risk acute myeloid leukemia. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Cut homeobox 1 (CUX1) is a transcription factor that contains three major domains, which include four DNA binding domains, three CUT domains or repeats (C1, C2, and C3), and a Cut homeodomain. It is expressed in multiple isoforms. |
| Immunogen: | CUX1 (AAH25422.1, 1 a.a. ~ 676 a.a) full-length human protein. Sequence MAANVGSMFQYWKRFDLQQLQRELD |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |