Anti-DMPK antibody produced in mouse
SIGMA/SAB1405719 - purified immunoglobulin, buffered aqueous solution
Synonym: DM; DM1; DM1PK; DMK; MDPK; MT-PK
Product Type: Chemical
Western Blotting Western Blot analysis of DMPK expression in transfected 293T cell line by DMPK polyclonal antibody. Lanes Lane 1: DMPK transfected lysate (69.19 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~69.4 kDa |
| NCBI accession no. | NM_004409.2   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q09013 |
| General description: | The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3′ untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. (provided by RefSeq) |
| Immunogen: | DMPK (NP_004400.4, 1 a.a. ~ 629 a.a) full-length human protein. Sequence MSAEVRLRRLQQLVLDPGFLGLEPL |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |