Anti-PTK2B antibody produced in mouse
SIGMA/SAB1405790 - purified immunoglobulin, buffered aqueous solution
Synonym: CADTK; CAKB; FADK2; FAK2; FRNK; PKB; PTK; PYK2; RAFTK
Product Type: Chemical
Western Blotting Western Blot analysis of PTK2B expression in transfected 293T cell line by PTK2B polyclonal antibody. Lanes Lane 1: PTK2B transfected lysate (110.99 kDa). Lane 2: Non-transfected lysate.
Western Blotting PTK2B polyclonal antibody. Western Blot analysis of PTK2B expression in rat brain.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~115.9 kDa |
| NCBI accession no. | BC036651.2   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q14289 |
| General description: | This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq) |
| Immunogen: | PTK2B (AAH36651.1, 1 a.a. ~ 1009 a.a) full-length human protein. Sequence MSGVSEPLSRVKLGTLRRPEGPAEP |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |