Anti-CFI antibody produced in mouse
SIGMA/SAB1405987 - purified immunoglobulin, buffered aqueous solution
Synonym: C3B-INA; FI; IF; KAF
Product Type: Chemical
Western Blotting Western Blot analysis of CFI expression in transfected 293T cell line by CFI polyclonal antibody. Lanes Lane 1: IF transfected lysate (41.47 kDa). Lane 2: Non-transfected lysate.
Western Blotting IF polyclonal antibody. Western Blot analysis of IF expression in human kidney.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~42.4 kDa |
| NCBI accession no. | BC020718.1   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P05156 |
| General description: | This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. (provided by RefSeq) |
| Immunogen: | CFI (AAH20718.1, 1 a.a. ~ 377 a.a) full-length human protein. Sequence MKLLHVFLLFLCFHLRFCKVTYTSQ |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |