Anti-KPNA2 antibody produced in mouse
SIGMA/SAB1406067 - purified immunoglobulin, buffered aqueous solution
Synonym: IPOA1; QIP2; RCH1; SRP1alpha
Product Type: Chemical
Western Blotting Western Blot analysis of KPNA2 expression in transfected 293T cell line by KPNA2 polyclonal antibody. Lanes Lane 1: KPNA2 transfected lysate (58.19 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~57.9 kDa |
| NCBI accession no. | NM_002266   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P52292 |
| General description: | The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination (provided by RefSeq) |
| Immunogen: | KPNA2 (NP_002257.1, 1 a.a. ~ 529 a.a) full-length human protein. Sequence MSTNENANTPAARLHRFKNKGKDST |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |