Anti-MAP2K3 antibody produced in mouse
SIGMA/SAB1406303 - purified immunoglobulin, buffered aqueous solution
Synonym: MAPKK3; MEK3; MKK3; PRKMK3
Product Type: Chemical
Western Blotting MAP2K3 polyclonal antibody. Western Blot analysis of MAP2K3 expression in A-431.
Western Blotting Western Blot analysis of MAP2K3 expression in transfected 293T cell line by MAP2K3 polyclonal antibody. Lanes Lane 1: MAP2K3 transfected lysate (38.17 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~39.3 kDa |
| NCBI accession no. | NM_145109.1   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P46734 |
| General description: | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. (provided by RefSeq) |
| Immunogen: | MAP2K3 (NP_659731.1, 1 a.a. ~ 347 a.a) full-length human protein. Sequence MESPASSQPASMPQSKGKSKRKKDL |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |