Anti-PTPN2 antibody produced in mouse
SIGMA/SAB1406343 - purified immunoglobulin, buffered aqueous solution
Synonym: PTPT; TC-PTP; TCELLPTP; TCPTP
Product Type: Chemical
Western Blotting Western Blot analysis of PTPN2 expression in transfected 293T cell line by PTPN2 polyclonal antibody. Lanes Lane 1: PTPN2 transfected lysate (42.57 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~45.2 kDa |
| NCBI accession no. | NM_080422.1   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P17706 |
| General description: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. (provided by RefSeq) |
| Immunogen: | PTPN2 (NP_536347.1, 1 a.a. ~ 387 a.a) full-length human protein. Sequence MPTTIEREFEELDTQRRWQPLYLEI |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |