Anti-HDAC6 antibody produced in mouse
SIGMA/SAB1406911 - purified immunoglobulin, buffered aqueous solution
Synonym: FLJ16239; HD6; JM21
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to HDAC6 on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting Western Blot analysis of HDAC6 expression in transfected 293T cell line by HDAC6 polyclonal antibody. Lanes Lane 1: HDAC6 transfected lysate (133.65 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~131.4 kDa |
| NCBI accession no. | NM_006044.2   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | Q9UBN7 |
| Application: | Anti-histone deacetylase 6 (HDAC6) antibody has been used in Western blotting. |
| Biochem/physiol Actions: | Histone deacetylase 6 (HDAC6) deacetylates substrates like α-tubulin. It is involved in endocytosis and autophagy. HDAC6 functions in cellular mechanisms connected to cancer and modulates cell motility. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. (provided by RefSeq) |
| Immunogen: | HDAC6 (NP_006035.2, 1 a.a. ~ 1215 a.a) full-length human protein. Sequence MTSTGQDSTTTRQRRSRQNPQSPPQ |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |