Anti-OPTN antibody produced in mouse
SIGMA/SAB1406930 - purified immunoglobulin, buffered aqueous solution
Synonym: FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to OPTN on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting OPTN polyclonal antibody. Western Blot analysis of OPTN expression in human placenta.
Western Blotting Western Blot analysis of OPTN expression in transfected 293T cell line by OPTN polyclonal antibody. Lanes Lane 1: OPTN transfected lysate (63.47 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~65.9 kDa |
| NCBI accession no. | NM_001008211   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | Q96CV9 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. (provided by RefSeq) |
| Immunogen: | OPTN (NP_001008212.1, 1 a.a. ~ 577 a.a) full-length human protein. Sequence MSHQPLSCLTEKEDSPSESTGNGPP |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |