Anti-DNAI1 antibody produced in mouse
SIGMA/SAB1407326 - purified immunoglobulin, buffered aqueous solution
Synonym: CILD1; ICS; ICS1; MGC26204; PCD
Product Type: Chemical
Western Blotting Western Blot analysis of DNAI1 expression in transfected 293T cell line by DNAI1 polyclonal antibody. Lanes Lane 1: DNAI1 transfected lysate (76.89 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~79.3 kDa |
| NCBI accession no. | NM_012144.2   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q9UI46 |
| Application: | Anti-DNAI1 antibody produced in mouse is suitable for western blot analysis. |
| Biochem/physiol Actions: | DNAI1 (Dynein axonemal intermediate chain 1) encodes an intermediate of outer dynein arms (ODA) proteins of cilia. Mutation in DNAI1 gene causes a trilogy syndrome named as Kartagener syndrome (KS), a rare recessive hereditary disorder named primary ciliary dyskinesia (PCD). |
| General description: | The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. (provided by RefSeq) |
| Immunogen: | DNAI1 (NP_036276.1, 1 a.a. ~ 699 a.a) full-length human protein. Sequence MIPASAKAPHKQPHKQSISIGRGTR |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |