Anti-LRSAM1 antibody produced in mouse
SIGMA/SAB1408175 - purified immunoglobulin, buffered aqueous solution
Synonym: FLJ31641; RIFLE; TAL
Product Type: Chemical
Western Blotting Western Blot analysis of LRSAM1 expression in transfected 293T cell line by LRSAM1 polyclonal antibody. Lanes Lane 1: LRSAM1 transfected lysate (79.53 kDa). Lane 2: Non-transfected lysate.
Western Blotting LRSAM1 polyclonal antibody. Western Blot analysis of LRSAM1 expression in human liver.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~83.6 kDa |
| NCBI accession no. | NM_001005373.1   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q6UWE0 |
| Application: | Anti-LRSAM1 antibody produced in mouse is suitable for western blot applications. |
| Biochem/physiol Actions: | LRSAM1 (leucine-rich repeat and sterile α motif-containing protein 1) is an E3 type ubiquitin ligase involved in membrane vesicle fusion during viral maturation and neuronal adhesion during muscle control activity. It binds to Tsg101 (tumor susceptibility gene 101) to ubiquitinate it, which further inactivates Tsg101-mediated sorting of endocytic (epidermal growth factor receptors) and exocytic (viral proteins) cargoes. It also protects cytoplasm from invasive pathogens by participating in ubiquitination associated with intracellular bacteria. Mutations in LRSAM1 cause Charcot-Marie-Tooth (CMT) disease. |
| General description: | LRSAM1 is a multifunctional RING finger protein that selectively regulates cell adhesion molecules, has ubiquitin ligase activity, and plays a role in receptor endocytosis and viral budding (Li et al., 2003 [PubMed 14635195]; Amit et al., 2004 [PubMed 15256501]).[supplied by OMIM |
| Immunogen: | LRSAM1 (NP_001005373.1, 1 a.a. ~ 723 a.a) full-length human protein. Sequence MPLFFRKRKPSEEARKRLEYQMCLA |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |