Anti-MCHR1 antibody produced in rabbit
SIGMA/SAB1408582 - purified immunoglobulin, buffered aqueous solution
Synonym: GPR24; MCH1R; MGC32129; SLC1
Product Type: Chemical
Western Blotting MCHR1 rabbit polyclonal antibody. Western Blot analysis of MCHR1 expression in IMR-32.
Western Blotting Western Blot analysis of MCHR1 expression in transfected 293T cell line by MCHR1 polyclonal antibody. Lanes Lane 1: MCHR1 transfected lysate (46.00 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~46 kDa |
| NCBI accession no. | BC021146   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q99705 |
| Application: | Anti-MCHR1 antibody produced in rabbit is suitable for western blot analysis. |
| Biochem/physiol Actions: | MCHR1 (melanin-concentrating hormone receptor 1) is involved in various biological processes such as in regulation of energy balance, food intake, physical activity and body weight. It is majorly associated with the neurotransmitter and neuropeptide systems, which are a part of regulation of food intake and energy balance. It forms complex with G proteins to inhibit adenylyl cyclase and with G proteins that activate phosphoinositide hydrolysis. The gene is associated with the schizophrenia disease since it has influence on schizophrenia susceptibility. It mediates Gα(i)-dependent signaling pathway. It has also been reported that MCHR1 regulates the orexigenic activity of melanin-concentrating hormone (MCH). |
| General description: | The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. (provided by RefSeq) |
| Immunogen: | MCHR1 (AAH21146.1, 1 a.a. ~ 422 a.a) full-length human protein. Sequence MSVGAMKKGVGRAVGLGGGSGCQAT |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |