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Monoclonal Anti-RRM1 antibody produced in mouse

SIGMA/SAB1409614 - clone 1D6, purified immunoglobulin, buffered aqueous solution

Synonym: R1; RIR1; RR1

Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SAB1409614-100UG 100 µg
$580.00
1/EA
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Western Blotting RRM1 monoclonal antibody, clone 1D6. Western Blot analysis of RRM1 expression in Raw 264.7.
Western Blotting Western Blot analysis of RRM1 expression in transfected 293T cell line by RRM1 monoclonal antibody, clone 1D6. Lanes Lane 1: RRM1 transfected lysate (Predicted MW: 90.1 kDa). Lane 2: Non-transfected lysate.
Western Blotting RRM1 monoclonal antibody, clone 1D6. Western Blot analysis of RRM1 expression in K-562.
Western Blotting QC Western Blot detection against Immunogen (47.41 kDa).

 

antibody form purified immunoglobulin
antibody product type primary antibodies
biological source mouse
clone 1D6, monoclonal
conjugate unconjugated
form buffered aqueous solution
isotype IgG2aκ
mol wt antigen 47.41 kDa
NCBI accession no. NM_001033.2 
Quality Level 100 
shipped in dry ice
species reactivity human, mouse
storage temp. −20°C
target post-translational modification unmodified
technique(s) indirect ELISA: suitable
  western blot: 1-5 μg/mL
UniProt accession no. P23921 
General description: This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. (provided by RefSeq)
Immunogen: RRM1 (NP_001024.1, 593 a.a. ~ 792 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
IRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS
Physical form: Solution in phosphate buffered saline, pH 7.4
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352203

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