Anti-FBXW4 antibody produced in mouse
SIGMA/SAB1409661 - purified immunoglobulin, buffered aqueous solution
Synonym: DAC; FBW4; FBWD4; SHFM3; SHSF3
Product Type: Chemical
Western Blotting Western Blot analysis of FBXW4 expression in transfected 293T cell line by FBXW4 polyclonal antibody. Lane1:FBXW4 transfected lysate (45.32 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 46.3 kDa |
| NCBI accession no. | NM_022039.3   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P57775 |
| General description: | This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. (provided by RefSeq) |
| Immunogen: | FBXW4 (NP_071322.1, 1 a.a. ~ 412 a.a) full-length human protein. Sequence MAAAAGEEEEEEEAARESAARPAAG |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |