Monoclonal Anti-BMP7 antibody produced in mouse
SIGMA/SAB1409674 - clone 2D6, purified immunoglobulin, buffered aqueous solution
Synonym: OP-1
Product Type: Chemical
Western Blotting Western Blot analysis of BMP7 expression in transfected 293T cell line by BMP7 monoclonal antibody, clone 2D6. Lanes Lane 1: BMP7 transfected lysate (49.565 kDa). Lane 2: Non-transfected lysate.
Western Blotting QC Western Blot detection against Immunogen (73.15 kDa).
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 2D6, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG2bκ |
| mol wt | antigen 73.15 kDa |
| NCBI accession no. | BC008584   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | P18075 |
| Biochem/physiol Actions: | BMP-7 induces apoptosis in B-cells. It has a role in organ development and may have a role in liver regeneration. Mutations in the gene encoding the protein have been shown to affect the development of teeth, palate and other orofacial complexes. |
| General description: | The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. (provided by RefSeq) |
| Immunogen: | BMP7 (AAH08584, 1 a.a. ~ 431 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MHVRSLRAAAPHSFVALWAPLFLLR |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |