Anti-DUSP6 antibody produced in rabbit
SIGMA/SAB1410312 - purified immunoglobulin, buffered aqueous solution
Synonym: MKP3; PYST1
Product Type: Chemical
Western Blotting Western Blot analysis of DUSP6 expression in transfected 293T cell line by DUSP6 polyclonal antibody. Lanes Lane 1: DUSP6 transfected lysate (42.30 kDa). Lane 2: Non-transfected lysate.
Western Blotting DUSP6 rabbit polyclonal antibody. Western Blot analysis of DUSP6 expression in human pancreas.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 42.3 kDa |
| NCBI accession no. | NM_001946   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q16828 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq) |
| Immunogen: | DUSP6 (NP_001937.2, 1 a.a. ~ 381 a.a) full-length human protein. Sequence MIDTLRPVPFASEMAISKTVAWLNE |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |