Anti-CNTNAP2 antibody produced in rabbit
SIGMA/SAB1410493 - purified immunoglobulin, buffered aqueous solution
Synonym: AUTS15; CASPR2; CDFE; DKFZp781D1846; NRXN4
Product Type: Chemical
Western Blotting Western Blot analysis of CNTNAP2 expression in transfected 293T cell line by CNTNAP2 polyclonal antibody. Lanes Lane 1: CNTNAP2 transfected lysate (148.20 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 148.2 kDa |
| NCBI accession no. | NM_014141.4   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q9UHC6 |
| Biochem/physiol Actions: | Contactin associated protein-like 2 (CNTNAP2) controls the spatial clustering of voltage-gated potassium channels Kv1.1 and Kv1.2. It has been reported that alteration in the CNTNAP2 gene expression causes mental retardation, autistic behavior, seizures and microcephaly. |
| General description: | This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons and associated with potassium channels. It may play a role in the local differentiation of the axon into distinct functional subdomains. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It may represent a positional candidate gene for the DFNB13 form of nonsyndromic deafness. (provided by RefSeq) |
| Immunogen: | CNTNAP2 (NP_054860.1, 1 a.a. ~ 1331 a.a) full-length human protein. Sequence MQAAPRAGCGAALLLWIVSSCLCRA |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |