Anti-GRN antibody produced in rabbit
SIGMA/SAB1410570 - purified immunoglobulin, buffered aqueous solution
Synonym: GEP; GP88; PCDGF; PEPI; PGRN
Product Type: Chemical
Western Blotting GRN rabbit polyclonal antibody. Western Blot analysis of GRN expression in mouse testis.
Western Blotting Western Blot analysis of GRN expression in transfected 293T cell line by GRN polyclonal antibody. Lanes Lane 1: GRN transfected lysate (63.50 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 63.5 kDa |
| NCBI accession no. | NM_002087   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P28799 |
| General description: | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. (provided by RefSeq) |
| Immunogen: | GRN (NP_002078.1, 1 a.a. ~ 593 a.a) full-length human protein. Sequence MWTLVSWVALTAGLVAGTRCPDGQF |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |