Anti-MMP12 antibody produced in rabbit
SIGMA/SAB1410791 - purified immunoglobulin, buffered aqueous solution
Synonym: HME; MGC138506; MME
Product Type: Chemical
Western Blotting Western Blot analysis of MMP12 expression in transfected 293T cell line by MMP12 polyclonal antibody. Lanes Lane 1: MMP12 transfected lysate (54.00 kDa). Lane 2: Non-transfected lysate.
Western Blotting MMP12 rabbit polyclonal antibody. Western Blot analysis of MMP12 expression in PC-12.
Western Blotting MMP12 rabbit polyclonal antibody. Western Blot analysis of MMP12 expression in HeLa.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 54 kDa |
| NCBI accession no. | NM_002426   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P39900 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP′s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (provided by RefSeq) |
| Immunogen: | MMP12 (NP_002417.2, 1 a.a. ~ 470 a.a) full-length human protein. Sequence MKFLLILLLQATASGALPLNSSTSL |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |