Anti-POMC antibody produced in rabbit
SIGMA/SAB1410992 - purified immunoglobulin, buffered aqueous solution
Product Type: Chemical
Western Blotting POMC rabbit polyclonal antibody. Western Blot analysis of POMC expression in rat brain.
Western Blotting Western Blot analysis of POMC expression in transfected 293T cell line by POMC polyclonal antibody. Lanes Lane 1: POMC transfected lysate (29.40 kDa). Lane 2: Non-transfected lysate.
Western Blotting POMC rabbit polyclonal antibody. Western Blot analysis of POMC expression in IMR-32.
Western Blotting POMC rabbit polyclonal antibody. Western Blot analysis of POMC expression in mouse liver.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 29.4 kDa |
| NCBI accession no. | NM_000939   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P01189 |
| General description: | This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. (provided by RefSeq) |
| Immunogen: | POMC (NP_000930.1, 1 a.a. ~ 267 a.a) full-length human protein. Sequence MPRSCCSRSGALLLALLLQASMEVR |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |