Anti-TDP1 antibody produced in rabbit
SIGMA/SAB1411073 - purified immunoglobulin, buffered aqueous solution
Synonym: FLJ11090; MGC104252
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to TDP1 on HeLa cell. [antibody concentration 20 μg/mL]
Western Blotting Western Blot analysis of TDP1 expression in transfected 293T cell line by TDP1 polyclonal antibody. Lanes Lane 1: TDP1 transfected lysate (68.40 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 68.4 kDa |
| NCBI accession no. | NM_001008744   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | Q9NUW8 |
| General description: | The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. (provided by RefSeq) |
| Immunogen: | TDP1 (NP_001008744.1, 1 a.a. ~ 608 a.a) full-length human protein. Sequence MSQEGDYGRWTISSSDESEEEKPKP |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |