Anti-PSME2 antibody produced in rabbit
SIGMA/SAB1411137 - purified immunoglobulin, buffered aqueous solution
Synonym: PA28B; PA28beta; REGbeta
Product Type: Chemical
Western Blotting PSME2 rabbit polyclonal antibody. Western Blot analysis of PSME2 expression in HepG2.
Western Blotting Western Blot analysis of PSME2 expression in transfected 293T cell line by PSME2 polyclonal antibody. Lanes Lane 1: PSME2 transfected lysate (27.40 kDa). Lane 2: Non-transfected lysate.
Western Blotting PSME2 rabbit polyclonal antibody. Western Blot analysis of PSME2 expression in mouse spleen.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 27.4 kDa |
| NCBI accession no. | BC004368.1   |
| shipped in | dry ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q9UL46 |
| General description: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. (provided by RefSeq) |
| Immunogen: | PSME2 (AAH04368.1, 1 a.a. ~ 239 a.a) full-length human protein. Sequence MAKPCGVRLSGEARKQVEVFRQNLF |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |