Anti-KIAA1967 antibody produced in rabbit
SIGMA/SAB1411159 - purified immunoglobulin, buffered aqueous solution
Synonym: DBC-1; DBC1
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to KIAA1967 on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting Western Blot analysis of KIAA1967 expression in transfected 293T cell line by KIAA1967 polyclonal antibody. Lanes Lane 1: KIAA1967 transfected lysate (102.90 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 102.9 kDa |
| NCBI accession no. | NM_021174   |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| western blot: 1 μg/mL |
| Biochem/physiol Actions: | KIAA1967 is associated with several cellular processes such as regulation of metabolism, aging and tumor biology. It plays a vital role in the cancer pathogenesis by participating in apoptosis, nuclear receptor function, cellular metabolism, circadian cycle and epigenetics. KIAA1967 acts as a regulator of various nuclear receptors such as ERα (oestrogen receptor α), ERβ, AR (androgen receptor), RAR (retinoic acid receptor) and haem receptor Rev-erbα. In addition to transcriptional activity, it also controls epigenetic modifiers such as the deacetylases HDAC3 and SIRT1, and the methyl-transferase SUV39H1. It has been reported that Nudix domain has the ability to bind nucleotides, which further could control its functional activities. In response to UV-induced DNA damage, it plays an important role in the maintenance of genomic stability and cellular integrity. KIAA1967 also possesses a significant role in adipocyte differentiation. |
| General description: | KIAA1967 is a large multi-domain containing nuclear protein mapped on chromosomal location 8p22. It consists of a NL (nuclear localization) motif, a CC (coiled-coil) domain responsible for the protein-protein interaction, an inactive EF-hand for Ca2+ binding, a Nudix domain, a RNA-binding domain and an LZ (leucine zipper) motif. |
| Immunogen: | KIAA1967 (NP_066997.3, 1 a.a. ~ 923 a.a) full-length human protein. Sequence MSQFKRQRINPLPGGRNFSGTASTS |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |