Anti-C2 antibody produced in rabbit
SIGMA/SAB1411361 - purified immunoglobulin, buffered aqueous solution
Synonym: CO2; DKFZp779M0311
Product Type: Chemical
Western Blotting Western Blot analysis of C2 expression in transfected 293T cell line by C2 polyclonal antibody. Lanes Lane 1: C2 transfected lysate (83.30 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 83.3 kDa |
| NCBI accession no. | NM_000063.3   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P06681 |
| General description: | Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined |
| Immunogen: | C2 (NP_000054.2, 1 a.a. ~ 752 a.a) full-length human protein. Sequence MGPLMVLFCLLFLYPGLADSAPSCP |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |