Anti-OTUB2 antibody produced in rabbit
SIGMA/SAB1411419 - purified immunoglobulin, buffered aqueous solution
Synonym: C14orf137; FLJ21916; MGC3102; OTB2; OTU2
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to OTUB2 on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting OTUB2 rabbit polyclonal antibody. Western Blot analysis of OTUB2 expression in mouse kidney.
Western Blotting OTUB2 rabbit polyclonal antibody. Western Blot analysis of OTUB2 expression in human kidney.
Western Blotting OTUB2 rabbit polyclonal antibody. Western Blot analysis of OTUB2 expression in rat brain.
Western Blotting OTUB2 rabbit polyclonal antibody. Western Blot analysis of OTUB2 expression in IMR-32.
Western Blotting Western Blot analysis of OTUB2 expression in transfected 293T cell line by OTUB2 polyclonal antibody. Lanes Lane 1: OTUB2 transfected lysate (27.20 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 27.2 kDa |
| NCBI accession no. | NM_023112.2   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | Q96DC9 |
| Biochem/physiol Actions: | OTU ubiquitin aldehyde binding 2 (OTUB2) possesses deubiquitinating enzymes (DUB) activity. It is capable of cleaving polyubiquitin chains, that are differently linked. It plays an important role in regulating the degradation of GLI family zinc finger 2 (Gli2) protein. OTUB2 can inhibit the death of human β cells. It is involved in immunity and viral infection. This protein can modulate nuclear factor κB (NF-κB) signaling pathway. OTUB2 might be associated with endometrial cancer. |
| General description: | OTU ubiquitin aldehyde binding 2 (OTUB2) is a de-ubiquitinating enzyme, which belongs to the ovarian tumor protease (OTU) subfamily of deubiquitinylases. It has an ovarian tumor (OTU) domain. OTUB2 gene is mapped to human chromosome 14q32. |
| Immunogen: | OTUB2 (NP_075601.1, 1 a.a. ~ 234 a.a) full-length human protein. Sequence MSETSFNLISEKCDILSILRDHPEN |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |