Anti-TNFSF11 antibody produced in rabbit
SIGMA/SAB1411542 - purified immunoglobulin, buffered aqueous solution
Synonym: CD254; ODF; OPGL; OPTB2; RANKL; TRANCE; hRANKL2; sOdf
Product Type: Chemical
Western Blotting Western Blot analysis of TNFSF11 expression in transfected 293T cell line by TNFSF11 polyclonal antibody. Lanes Lane 1: TNFSF11 transfected lysate (27.70 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 27.7 kDa |
| NCBI accession no. | NM_033012   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | O14788 |
| General description: | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. (provided by RefSeq) |
| Immunogen: | TNFSF11 (ENSP00000351347, 1 a.a. ~ 244 a.a) full-length human protein. Sequence MDPNRISEDGTHCIYRILRLHENAD |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |