Anti-LONP1 antibody produced in rabbit
SIGMA/SAB1411647 - purified immunoglobulin, buffered aqueous solution
Synonym: LON; LONP; LonHS; MGC1498; PIM1; PRSS15; hLON
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to LONP1 on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting Western Blot analysis of LONP1 expression in transfected 293T cell line by LONP1 polyclonal antibody. Lanes Lane 1: LONP1 transfected lysate (106.50 kDa). Lane 2: Non-transfected lysate.
Western Blotting LONP1 rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in human kidney.
Western Blotting LONP1 rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in HepG2.
Western Blotting LONP1 rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in mouse kidney.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 106.5 kDa |
| NCBI accession no. | NM_004793.2   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | P36776 |
| Biochem/physiol Actions: | Lon peptidase 1, mitochondrial (LONP1) is involved in various cellular processes such as DNA replication, membrane fusion, signal transduction and transcriptional regulation. Genetic variation in the gene leads to a multi-system developmental disorder called cerebral, ocular, dental, auricular, skeletal (CODAS) syndrome. Downregulated expression of this gene has been observed in hereditary spastic paraplegia patients. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Lon peptidase 1, mitochondrial (LONP1) is an ATP-dependent mitochondrial Lon protease, encoded by the gene mapped to human chromosome 19p13.3. The encoded protein is a member of the AAA+ superfamily of ATPases. |
| Immunogen: | LONP1 (NP_004784.2, 1 a.a. ~ 959 a.a) full-length human protein. Sequence MAASTGYVRLWGAARCWVLRRPMLA |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |