ANTI-MUS81 antibody produced in mouse
SIGMA/SAB1411928 - purified immunoglobulin, buffered aqueous solution
Synonym: FLJ21012; FLJ44872; MUS81
Product Type: Chemical
Western Blotting MUS81 polyclonal antibody. Western Blot analysis of MUS81 expression in human liver.
Western Blotting Western Blot analysis of MUS81 expression in transfected 293T cell line by MUS81 polyclonal antibody. Lanes Lane 1: MUS81 transfected lysate (60.61 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 61.1 kDa |
| NCBI accession no. | NM_025128.3   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q96NY9 |
| Biochem/physiol Actions: | MUS81 plays a vital role in the metabolism of replication intermediates. In mammals, MUS81 interacts with the non-catalytic subunits essential meiotic structure-specific endonuclease (EME) 1 or EME 2 to form heterodimer complexes. These complexes have the ability to cleave replication forks (RFs) in vitro. Downregulated expression of Mus81 enhances the sensitivity of colon cancer cells to chemotherapeutic drugs by inducing S phase arrest and apoptosis through CHK1 pathway activation. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | MUS81 structure-specific endonuclease subunit is a DNA repair gene, mapped to human chromosome 11q13.1. The encoded protein belongs to the XPF/ ERCC4 (xeroderma pigmentosum, complementation group F) protein family. |
| Immunogen: | MUS81 (NP_079404.2, 1 a.a. ~ 551 a.a) full-length human protein. Sequence MAAPVRLGRKRPLPACPNPLFVRWL |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |