Anti-AMOT (ab2) antibody produced in rabbit
SIGMA/SAB2100116 - affinity isolated antibody
Synonym: Anti-Angiomotin; Anti-KIAA1071
Product Type: Chemical
Immunohistochemistry AMOT Antibody: Cat. No. SAB2100116: Immunohistochemistry analysis of AMOT in heart with AMOT Antibody 1.0 μg/mL. Observed Staining: Membrane(tight junctions - intercalated disks)
Immunoblotting Anti-AMOT (ab2): Cat. No.SAB2100116: AMOT in Fetal Heart tissue lysate with AMOT antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| mol wt | 73 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, bovine, dog, rabbit, horse, guinea pig, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q4VCS5  |
| Biochem/physiol Actions: | AMOT belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human AMOT |
| Other Notes: | Synthetic peptide located within the following region: TANKQLAEKEYEGSEDTRKTISQLF |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |