Anti-BACE1 antibody produced in rabbit
SIGMA/SAB2100200 - affinity isolated antibody
Synonym: Anti-β-Site APP-cleaving enzyme 1; Anti-ASP2; Anti-BACE; Anti-FLJ90568; Anti-HSPC104
MDL Number: MFCD03096637
Product Type: Chemical
Immunohistochemistry Anti-BACE1: Cat. No. SAB2100200: Immunohistochemistry of BACE1 in Adrenal tissue with BACE1 antibody at 4-8 μg/mL.
Immunohistochemistry Anti-BACE1: Cat. No. SAB2100200: Immunohistochemistry of BACE1 in Testis tissue with BACE1 antibody at 4-8 μg/mL.
Immunohistochemistry Anti-BACE1: Cat. No. SAB2100200: Immunohistochemistry of BACE1 in Mouse astrocytes tissue with BACE1 antibody at 2-10 μg/mL.
Immunoblotting Anti-BACE1: Cat. No.SAB2100200: BACE1 in Fetal Liver tissue lysate with BACE1 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 51 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | rabbit, bovine, guinea pig, mouse, rat, horse, dog, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| western blot: suitable | |
| UniProt accession no. | P56817  |
| Biochem/physiol Actions: | β-site APP cleaving enzyme (BACE-1) acts as a rate-limiting enzyme of amyloid-β-peptide (Aβ). Overexpression of BACE-1 leads to increased β-secretase activity. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | β-site APP cleaving enzyme (BACE-1) is known as β-secretase. It consists of an N-terminal signal peptide (SP), a pro-peptide (Pro) domain, a catalytic domain, a transmembrane domain and a C-terminal tail. |
| General description: | BACE1, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human BACE1 |
| Other Notes: | Synthetic peptide located within the following region: GQGYYVEMTVGSPPQTLNILVDTGS |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |