Anti-BCL11A antibody produced in rabbit
SIGMA/SAB2100215 - affinity isolated antibody
Synonym: Anti-B-cell CLL/lymphoma 11A (zinc finger protein); Anti-BCL11A-L; Anti-BCL11A-S; Anti-BCL11A-XL; Anti-CTIP1
Product Type: Chemical
Immunohistochemistry Anti-BCL11A: Cat. No. SAB2100215: Immunohistochemistry of BCL11A in Human Spleen tissue with BCL11A antibody at 5.0 μg/mL.
Immunoblotting Anti-BCL11A: Cat. No.SAB2100215: BCL11A in Fetal Heart tissue lysate with BCL11A antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 91 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | horse, mouse, rat, human, dog, bovine, pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q9H165  |
| Biochem/physiol Actions: | BCL11A Is a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression.This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human BCL11A |
| Other Notes: | Synthetic peptide located within the following region: MSRRKQGKPQHLSKREFSPEPLEAI |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |