Anti-CREBBP antibody produced in rabbit
SIGMA/SAB2100480 - affinity isolated antibody
Synonym: Anti-CBP; Anti-CREB binding protein (Rubinstein-Taybi syndrome); Anti-KAT3A; Anti-RSTS; Anti-RTS
MDL Number: MFCD02262673
Product Type: Chemical
Immunohistochemistry Anti-CREBBP: Cat. No. SAB2100480: Immunohistochemistry of CREBBP in Human Colon tissue with CREBBP antibody at 5.0 μg/mL.
Immunohistochemistry Immunohistochemistry of CREBBP in Human Colon with CREBBP antibody at 4-8 μg/mL
Immunoblotting Anti-CREBBP: Cat. No.SAB2100480: CREBBP in Jurkat cell lysate with CREBBP antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 261 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | bovine, dog, mouse, horse, human, rabbit, rat, guinea pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q92793  |
| Biochem/physiol Actions: | CREBBP is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The previously assigned protein identifier Q4LE28 has been merged into Q92793. Full details can be found on the UniProt database. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human CREBBP |
| Other Notes: | Synthetic peptide located within the following region: TPAASQALNPQAQKQVGLATSSPAT |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |