Anti-CYP46A1 antibody produced in rabbit
SIGMA/SAB2100523 - affinity isolated antibody
Synonym: Anti-CP46; Anti-CYP46; Anti-Cytochrome P450, family 46, subfamily A, polypeptide 1
Product Type: Chemical
Immunoblotting Anti-CYP46A1: Cat. No.SAB2100523: CYP46A1 in HepG2 cell lysate with CYP46A1 antibody at 1.0 μg/mL.
Immunoblotting CYP46A1: Cat. No. SAB2100523: Western blot analysis of CYP46A1 in Human Adult Placenta cell lysates with CYP46A1 antibody at 1.0 μg/mL.
Western Blotting Western Blot of CYP46A1 in Human PANC1 with CYP46A1 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 57 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | bovine, guinea pig, rat, human, mouse, horse, goat, dog |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q9Y6A2  |
| Biochem/physiol Actions: | CYP46A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human CYP46A1 |
| Other Notes: | Synthetic peptide located within the following region: YVMGRMDTYFEDPLTFNPDRFGPGA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |