Anti-DTL antibody produced in rabbit
SIGMA/SAB2100630 - affinity isolated antibody
Synonym: Anti-CDT2; Anti-DCAF2; Anti-Denticleless homolog (Drosophila); Anti-L2DTL; Anti-RAMP
Product Type: Chemical
Immunoblotting Anti-DTL: Cat. No.SAB2100630: DTL in 721_B cell lysate with DTL antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 79 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | mouse, guinea pig, human, dog, rat, bovine, horse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q9NZJ0  |
| Biochem/physiol Actions: | DTL is required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. It seems to be necessary to ensure proper cell cycle regulation of DNA replication. DTL may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. It also may play a role in cell proliferation of NT2 embryonal carcinoma cells. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human DTL |
| Other Notes: | Synthetic peptide located within the following region: VNQISGAHNTSDKQTPSKPKKKQNS |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |