Anti-F13B antibody produced in rabbit
SIGMA/SAB2100738 - affinity isolated antibody
Synonym: Anti-Coagulation factor XIII, B polypeptide; Anti-FXIIIB
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of F13B in Human Fetal Liver with F13B antibody at 4-8 μg/mL
Immunohistochemistry Immunohistochemistry of F13B in Human Vessel with F13B antibody at 4-8 μg/mL
Immunoblotting Anti-F13B: Cat. No.SAB2100738: F13B in HeLa cell lysate with F13B antibody at 1.0 μg/mL.
Western Blotting Western Blot of F13B in Human DLD1 with F13B antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 73 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, mouse, rat, bovine, guinea pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | P05160  |
| Biochem/physiol Actions: | F13B contains 10 Sushi (CCP/SCR) domains. The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Defects in F13B can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-ly |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human F13B |
| Other Notes: | Synthetic peptide located within the following region: LRLIENGYFHPVKQTYEEGDVVQFF |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |