Anti-FBXW2 antibody produced in rabbit
SIGMA/SAB2100800 - affinity isolated antibody
Synonym: Anti-F-box and WD repeat domain containing 2; Anti-FBW2; Anti-Fwd2; Anti-MGC117371; Anti-Md6
Product Type: Chemical
Immunoblotting Anti-FBXW2: Cat. No.SAB2100800: FBXW2 in Jurkat cell lysate with FBXW2 antibody at 1.0 μg/mL.
Immunoblotting FBXW2: Cat. No. SAB2100800: Western blot analysis of FBXW2 in Human Adult Placenta cell lysates with FBXW2 antibody at 1.0 μg/mL.
Immunoblotting FBXW2: Cat. No. SAB2100800: Western blot analysis of FBXW2 in Human Fetal Heart cell lysates with FBXW2 antibody at 1.0 μg/mL.
Immunoblotting FBXW2: Cat. No. SAB2100800: Western blot analysis of FBXW2 in Human Fetal Liver cell lysates with FBXW2 antibody at 1.0 μg/mL.
Immunoblotting FBXW2: Cat. No. SAB2100800: Western blot analysis of FBXW2 in Human Fetal Lung cell lysates with FBXW2 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 51 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | guinea pig, rat, bovine, mouse, horse, rabbit, human, dog |
| storage temp. | −20°C |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q9UKT8  |
| Biochem/physiol Actions: | F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. FBXW2 is the second identified member of the F-box family and contains multiple WD-40 repeats.F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human FBXW2 |
| Other Notes: | Synthetic peptide located within the following region: SLISRWPLPEYRKSKRGSSFLAGEA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |