Anti-GJA1 antibody produced in rabbit
SIGMA/SAB2100918 - affinity isolated antibody
Synonym: Anti-CX43; Anti-DFNB38; Anti-GJAL; Anti-Gap junction protein, α 1, 43kDa; Anti-ODDD
MDL Number: MFCD00803532
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of GJA1 in Human Thyroid Gland with GJA1 antibody at 4-8 μg/mL
Immunoblotting Anti-GJA1: Cat. No.SAB2100918: GJA1 in Fetal Liver tissue lysate with GJA1 antibody at 1.0 μg/mL.
Western Blotting Western Blot of GJA1 in Rat with GJA1 antibody at 1 μg/mL
Western Blotting Western Blot of GJA1 in Rat cardiac with GJA1 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 43 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | dog, horse, human, rabbit, guinea pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | P17302  |
| Biochem/physiol Actions: | Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human GJA1 |
| Other Notes: | Synthetic peptide located within the following region: GSTISNSHAQPFDFPDDNQNSKKLA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |