Anti-GPNMB antibody produced in rabbit
SIGMA/SAB2100957 - affinity isolated antibody
Synonym: Anti-Glycoprotein (transmembrane) nmb; Anti-HGFIN; Anti-NMB
Product Type: Chemical
Immunohistochemistry Anti-GPNMB: Cat. No. SAB2100957: Immunohistochemistry of GPNMB in HepG2 cell lysate tissue with GPNMB antibody at 1 μg/mL.
Immunoblotting Anti-GPNMB: Cat. No.SAB2100957: GPNMB in 293T cell lysate with GPNMB antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 60 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | rat, horse, mouse, guinea pig, human |
| storage temp. | −20°C |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q14956  |
| Biochem/physiol Actions: | GPNMB is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human GPNMB |
| Other Notes: | Synthetic peptide located within the following region: KGGRVQAVLTSDSPALVGSNITFAV |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |