Anti-HDAC1 antibody produced in rabbit
SIGMA/SAB2101020 - affinity isolated antibody
Synonym: Anti-DKFZp686H12203; Anti-GON-10; Anti-HD1; Anti-Histone deacetylase 1; Anti-RPD3
MDL Number: MFCD01633420
Product Type: Chemical
Immunohistochemistry HDAC1 Antibody: Cat. No. SAB2101020: Immunohistochemistry analysis of HDAC1 in Human Heart with HDAC1 Antibody Antibody Concentration: 4.0-8.0 μg/mL. Cellular Data: Epithelial cells of renal tubule
Immunoblotting Anti-HDAC1: Cat. No.SAB2101020: HDAC1 in Jurkat cell lysate with HDAC1 antibody at 1.0 μg/mL.
Immunoblotting HDAC1: Cat. No. SAB2101020: Western blot analysis of HDAC1 in Human Fetal Heart cell lysates with HDAC1 antibody at 1.0 μg/mL.
Immunoblotting HDAC1: Cat. No. SAB2101020: Western blot analysis of HDAC1 in Human Fetal Liver cell lysates with HDAC1 antibody at 1.0 μg/mL.
Immunoblotting HDAC1: Cat. No. SAB2101020: Western blot analysis of HDAC1 in Human Fetal Lung cell lysates with HDAC1 antibody at 1.0 μg/mL.
Immunoblotting HDAC1: Cat. No. SAB2101020: Western blot analysis of HDAC1 in Human Adult Placenta cell lysates with HDAC1 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 55 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | yeast, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q13547  |
| Biochem/physiol Actions: | Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human HDAC1 |
| Other Notes: | Synthetic peptide located within the following region: EKIKQRLFENLRMLPHAPGVQMQAI |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |