Anti-HSD11B1 antibody produced in rabbit
SIGMA/SAB2101084 - affinity isolated antibody
Synonym: Anti-11-β-HSD1; Anti-11-DH; Anti-HDL; Anti-HSD11; Anti-Hydroxysteroid (11-β) dehydrogenase 1
MDL Number: MFCD08064405
Product Type: Chemical
Immunohistochemistry Anti-HSD11B1: Cat. No. SAB2101084: Immunohistochemistry of HSD11B1 in Human Liver tissue with HSD11B1 antibody at 5.0 μg/mL.
Immunoblotting Anti-HSD11B1: Cat. No.SAB2101084: HSD11B1 in Fetal Liver tissue lysate with HSD11B1 antibody at 1.0 μg/mL.
Western Blotting Western Blot of HSD11B1 in Transient overexpression lysate of HSD11B1 and Non-overexpressed vector control lysate with HSD11B1 antibody at 1 μg/mL
Western Blotting Western Blot of HSD11B1 in Rat Liver with HSD11B1 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| application(s) | research pathology |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 32 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, mouse, rat, guinea pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P28845  |
| Biochem/physiol Actions: | Mutation in the hydroxysteroid 11-β dehydrogenase 1 (HSD11B1) gene is implicated in cortisone reductase deficiency. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) short-chain dehydrogenase/reductase superfamily and anchors on the endoplasmic reticulum (ER) membrane. It comprises a hydrophobic N terminus and a catalytic domain. The HSD11B1 gene is mapped to human chromosome location 1q32.2. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human HSD11B1 |
| Other Notes: | Synthetic peptide located within the following region: QKVVSHCLELGAASAHYIAGTMEDM |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |