Anti-HTR2A antibody produced in rabbit
SIGMA/SAB2101106 - affinity isolated antibody
Synonym: Anti-5-HT2A; Anti-
Product Type: Chemical
Immunoblotting Anti-HTR2A: Cat. No.SAB2101106: HTR2A in 721_B cell lysate with HTR2A antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 52 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | P28223  |
| Biochem/physiol Actions: | 5-hydroxytryptamine receptor 2A (HTR2A) binds to neurotransmitters or drugs and activates the G-protein coupled signalling pathway by stimulating phospholipase C signalling cascade and the ultimate release of calcium. and modulates cognitive functions, memory, learning etc. HTR2A is the drug targeting receptor for many of the antipsychotic drugs like serotonergic psychedelics. Genetic polymorphisms as well as epigenetic factors regulate the expression of HTR2A. These variations in the regulation lead to a wide variety of psychotic disorders like schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive-compulsive disorder, eating disorders, and Alzheimer′s disease. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | 5-hydroxytryptamine receptor 2A (HTR2A) encodes for a G-Protein coupled serotonin receptor. HTR2A is predominantly expressed in the brain near to serotoninergic neurons. The gene HTR2A is localized on human chromosome on 13q14.2. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human HTR2A |
| Other Notes: | Synthetic peptide located within the following region: DILCEENTSLSSTTNSLMQLNDDTR |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |