Anti-IGF1R antibody produced in rabbit
SIGMA/SAB2101136 - affinity isolated antibody
Synonym: Anti-CD221; Anti-IGFIR; Anti-Insulin-like growth factor 1 receptor; Anti-JTK13; Anti-MGC142170
MDL Number: MFCD00282340
Product Type: Chemical
Immunohistochemistry Anti-IGF1R: Cat. No. SAB2101136: Immunohistochemistry of IGF1R in Mouse skelatal muscle tissue with IGF1R antibody at 1-10 μg/mL.
Immunoblotting Anti-IGF1R: Cat. No.SAB2101136: IGF1R in Jurkat cell lysate with IGF1R antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 71 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | pig, horse, sheep, bovine, dog, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| western blot: suitable | |
| UniProt accession no. | P08069  |
| Biochem/physiol Actions: | Insulin-like growth factor 1 receptor (IGF1R) is prime for IGF-1 for its mitogenic and metabolic functionality. It binds to IGF1 and IGF2 and activates phosphatidylinositol 3?kinase (PI3K)/protein kinase B (AKT) and mitogen-activated protein kinase pathways. IGF1R plays a key role in growth, differentiation, cell metabolic events, and apoptosis. It also favors proliferation in the myelodysplastic syndrome (MDS) and may serve as a potential target to treat MDS. Mutations in the IGF1R gene are implicated in the pre- and postnatal growth retardation and microcephaly. High levels of IGF1R overexpression are observed in multiple myeloma, lung, breast, bladder and pancreatic tumors. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Insulin-like growth factor 1 receptor (IGF1R), a transmembrane tyrosine kinase receptor, belongs to the insulin receptor family. It comprises juxtamembrane (JM) and transmembrane domains that harbor substrate binding sites. Structurally, IGF1R exists as a tetramer α2/β2 with the extracellular dimeric α subunits. The IGF1R gene is mapped to human chromosome 15q26.3. |
| Immunogen: | Synthetic peptide directed towards the middle region of human IGF1R |
| Other Notes: | Synthetic peptide located within the following region: DRHSGHKAENGPGPGVLVLRASFDE |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |