Anti-IKZF1 antibody produced in rabbit
SIGMA/SAB2101144 - affinity isolated antibody
Synonym: Anti-Hs.54452; Anti-IK1; Anti-IKAROS; Anti-IKAROS family zinc finger 1 (Ikaros); Anti-LYF1
Product Type: Chemical
Immunoblotting Anti-IKZF1: Cat. No.SAB2101144: IKZF1 in HeLa cell lysate with IKZF1 antibody at 1.0 μg/mL.
Immunoblotting IKZF1: Cat. No. SAB2101144: Western blot analysis of IKZF1 in Human Adult Placenta cell lysates with IKZF1 antibody at 1.0 μg/mL.
Immunoblotting IKZF1: Cat. No. SAB2101144: Western blot analysis of IKZF1 in Human Fetal Muscle cell lysates with IKZF1 antibody at 1.0 μg/mL.
Immunoblotting IKZF1: Cat. No. SAB2101144: Western blot analysis of IKZF1 in Human Fetal Liver cell lysates with IKZF1 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 57 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, horse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q13422  |
| Biochem/physiol Actions: | Ikaros positively regulates lymphocyte differentiation and negatively regulates cell proliferation. It plays a role in peripheral lymphocyte homeostasis and negatively regulates follicular B cell activation. Ikaros/IKZF1 is involved in the development of myeloid cells such as red blood cells, platelets, basophils, and neutrophils. Mutations in the IKZF1 gene lead to acute lymphoblastic leukemia (ALL). Downregulation of the IKZF1 gene is observed in the peripheral blood mononuclear cells of systemic lupus erythematosus (SLE) patients. IKZF1 binds and activates the enhancer (delta-A element) of the CD3-delta gene. It functions in the specification and the maturation of the T-lymphocyte. It also interacts with a critical control element in the terminal deoxynucleotidyltransfera |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The Ikaros family zinc finger 1 (IKZF1) gene encodes for the Ikaros transcription factor, and is expressed throughout hematopoiesis. IKZF1 protein is made of an N-terminal DNA-binding domain (DBD) and a C-terminal dimerization domain. The IKZF1 gene is mapped on the human chromosome at 7p12.2. |
| Immunogen: | Synthetic peptide directed towards the middle region of human IKZF1 |
| Other Notes: | Synthetic peptide located within the following region: DLCKIGSERSLVLDRLASNVAKRKS |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |