Anti-KCNN2 antibody produced in rabbit
SIGMA/SAB2101228 - affinity isolated antibody
Synonym: Anti-HSK2; Anti-KCNN2; Anti-KCa2.2; Anti-SK2; Anti-SKCA2
MDL Number: MFCD02097223
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of KCNN2 in Rhesus macaque spinal cord with KCNN2 antibody at 4-8 μg/mL
Immunoblotting Anti-KCNN2: Cat. No.SAB2101228: KCNN2 in Fetal Muscle tissue lysate with KCNN2 antibody at 1.0 μg/mL.
Western Blotting Western Blot of KCNN2 in Human Fetal Heart with KCNN2 antibody at 1 μg/mL
Western Blotting Western Blot of KCNN2 in Human Fetal Lung with KCNN2 antibody at 1 μg/mL
Western Blotting Western Blot of KCNN2 in Human Fetal Muscle with KCNN2 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 26 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | guinea pig, mouse, rabbit, dog, horse, human, rat, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q6PJI0  |
| Biochem/physiol Actions: | KCNN2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This protein is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for KCNN2.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human KCNN2 |
| Other Notes: | Synthetic peptide located within the following region: KNAAANVLRETWLIYKNTKLVKKID |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |