Anti-MAFB antibody produced in rabbit
SIGMA/SAB2101415 - affinity isolated antibody
Synonym: Anti-KRML; Anti-MGC43127; Anti-V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
MDL Number: MFCD07370390
Product Type: Chemical
Immunoblotting Anti-MAFB: Cat. No.SAB2101415: MAFB in Fetal Muscle tissue lysate with MAFB antibody at 1.0 μg/mL.
Immunoblotting MAFB: Cat. No. SAB2101415: Western blot analysis of MAFB in Human Fetal Heart cell lysates with MAFB antibody at 1.0 μg/mL.
Immunoblotting MAFB: Cat. No. SAB2101415: Western blot analysis of MAFB in Human Fetal Lung cell lysates with MAFB antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 36 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, rat, guinea pig, horse, bovine, mouse, dog |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q9Y5Q3  |
| Biochem/physiol Actions: | MAF bZIP transcription factor B (MAFB) has been implicated in the development of the hindbrain structures, thymus, interneurons, pancreatic islet cells and the hematopoietic system. In mouse, it helps in lip and palate development. MAFB regulates lineage-specific gene expression by suppressing the Ets-1-mediated transcription. The encoded protein plays an essential role in islet α-cell function. In addition, MAFB also regulates genes involved in both endocrine α- and β-cell differentiation. The protein acts as a modulator and marker of adipose tissue inflammation. Mutations in the gene is associated with the development of multicentric carpo-tarsal osteolysis (MCTO). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | MAF bZIP transcription factor B (MAFB) is encoded by the gene mapped to human chromosome 20q12. The encoded protein is a member of the maf oncogene family and is ubiquitously expressed in variety of tissues. MAFB is a 311 amino acid protein characterized with a typical basic leucine zipper (bZIP) domain in its C-terminal region. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human MAFB |
| Other Notes: | Synthetic peptide located within the following region: APQGSATAAEPQPGDPARASQDSAD |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |