Anti-NFATC1 (ab1) antibody produced in rabbit
SIGMA/SAB2101576 - affinity isolated antibody
Synonym: Anti-MGC138448; Anti-NFAT2; Anti-Nuclear factor of activated T-cells, cytoplasmic, calcineurin-
Product Type: Chemical
Immunohistochemistry NFATC1 Antibody: Cat. No. SAB2101576: Immunohistochemistry analysis of NFATC1 in heart with NFATC1 Antibody 1.0 μg/mL. Observed Staining: Nuclear, Cytoplasmic
Immunoblotting Anti-NFATC1 (ab1): Cat. No.SAB2101576: NFATC1 in Jurkat cell lysate with NFATC1 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 78 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | O95644  |
| Biochem/physiol Actions: | NFATC1 is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Different isoforms of this protein may regulate inducible expression of different cytokine genes.The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The previously assigned protein identifier Q2M1S3 has been merged into O95644. Full details can be found on the UniProt database. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human NFATC1 |
| Other Notes: | Synthetic peptide located within the following region: PSTSFPVPSKFPLGPAAAVFGRGET |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |