Anti-PLP1 (ab1) antibody produced in rabbit
SIGMA/SAB2101830 - affinity isolated antibody
Synonym: Anti-MMPL; Anti-PLP; Anti-PLP/DM20; Anti-PMD; Anti-Proteolipid protein 1 (Pelizaeus-
MDL Number: MFCD01322366
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of PLP1 in Human Brain with PLP1 antibody at 4-8 μg/mL
Immunoblotting Anti-PLP1 (ab1): Cat. No.SAB2101830: PLP1 in 721_B cell lysate with PLP1 antibody at 1.0 μg/mL.
Western Blotting Western Blot of PLP1 in Mouse Spleen with PLP1 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 30 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | guinea pig, horse, dog, bovine, mouse, human, rabbit, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P60201  |
| Biochem/physiol Actions: | PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5′ UTRs, have been identified for this gene.This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5′ UTRs, have been identified for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human PLP1 |
| Other Notes: | Synthetic peptide located within the following region: GHEALTGTEKLIETYFSKNYQDYEY |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |