Anti-RARA antibody produced in rabbit
SIGMA/SAB2101946 - affinity isolated antibody
Synonym: Anti-NR1B1; Anti-RAR; Anti-Retinoic acid receptor, α
MDL Number: MFCD00802878
Product Type: Chemical
Immunohistochemistry RARA Antibody: Cat. No. SAB2101946: Immunohistochemistry analysis of RARA in liver with RARA Antibody 1.0 μg/mL. Observed Staining: Cytoplasmic
Immunoblotting Anti-RARA: Cat. No.SAB2101946: RARA in Transfected 293T cell lysate with RARA antibody at 1.0 μg/mL.
Immunoblotting RARA: Cat. No. SAB2101946: Western blot analysis of RARA in Human Adult Placenta cell lysates with RARA antibody at 1.0 μg/mL.
Immunoblotting RARA Antibody: Cat. No. SAB2101946: Western Blot analysis of RARA in Transfected 293T cell lysates with RARA Antibody at 1.0 μg/mL.
Immunoblotting RARA: Cat. No. SAB2101946: Western blot analysis of RARA in Human Fetal Muscle cell lysates with RARA antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 51 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P10276-2  |
| Biochem/physiol Actions: | Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor, which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT, and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human RARA |
| Other Notes: | Synthetic peptide located within the following region: YESVEVGGPTPNPFLVVDFYNQNRA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |