Anti-STAT3 antibody produced in rabbit
SIGMA/SAB2102317 - affinity isolated antibody
Synonym: Anti-APRF; Anti-FLJ20882; Anti-MGC16063; Anti-Signal transducer and activator of transcription 3 (acute-phase response factor)
MDL Number: MFCD01092492
Product Type: Chemical
Immunohistochemistry Anti-STAT3: Cat. No. SAB2102317: Immunohistochemistry of STAT3 in Human kidney tissue with STAT3 antibody at 4-8 μg/mL.
Immunohistochemistry Anti-STAT3: Cat. No. SAB2102317: Immunohistochemistry of STAT3 in Human uterus tissue with STAT3 antibody at 4-8 μg/mL.
Immunohistochemistry Anti-STAT3: Cat. No. SAB2102317: Immunohistochemistry of STAT3 in Human prostate tissue with STAT3 antibody at 4-8 μg/mL.
Immunohistochemistry Anti-STAT3: Cat. No. SAB2102317: Immunohistochemistry of STAT3 in macrophage cell line J774 tissue with STAT3 antibody at 1/100.
Immunoblotting Anti-STAT3: Cat. No.SAB2102317: STAT3 in Fetal Liver tissue lysate with STAT3 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 88 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | rat, rabbit, guinea pig, horse, human, bovine, dog, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| western blot: suitable | |
| UniProt accession no. | B5BTZ6  |
| Biochem/physiol Actions: | STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. It mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human STAT3 |
| Other Notes: | Synthetic peptide located within the following region: AQWNQLQQLDTRYLEQLHQLYSDSF |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |