Anti-TAP1 antibody produced in rabbit
SIGMA/SAB2102370 - affinity isolated antibody
Synonym: Anti-ABC17; Anti-ABCB2; Anti-APT1; Anti-D6S114E; Anti-Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
MDL Number: MFCD00283209
Product Type: Chemical
Immunohistochemistry TAP1 Antibody: Cat. No. SAB2102370: Immunohistochemistry analysis of TAP1 in Human Lung Tissue with TAP1 Antibody 5.0 μg/mL. Observed Staining: Cytoplasmic in alveolar type I & II cells
Immunoblotting Anti-TAP1: Cat. No.SAB2102370: TAP1 in MCF7 cell lysate with TAP1 antibody at 1.0 μg/mL.
Western Blotting Western Blot of TAP1 in Human HeLa with TAP1 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 87 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q03518  |
| Application: | Anti-TAP1 antibody has been used in immunoprecipitation. |
| Biochem/physiol Actions: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). TAP1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. TAP1 is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Knockdown of PSF1 expression blocks the multiplication of cell in lung cancer cells in vitro. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The transporter protein associated with antigen processing-1 (TAP1) belongs to the major histocompatibility complex (MHC) class I peptide-loading complex. TAP1 is also termed as the partner of sld five 1 (PSF1). PSF1 belongs to the heterotetrameric complex, known as GINS. It is located on human chromosome 6p21. |
| Immunogen: | Synthetic peptide directed towards the middle region of human TAP1 |
| Other Notes: | Synthetic peptide located within the following region: LVTFVLYQMQFTQAVEVLLSIYPRV |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |